Featured Publications
Hyperpolarized 13C metabolic imaging of the human abdomen with spatiotemporal denoising
Authors: Nickels TM, Kim Y, Lee PM, Chen HY, Ohliger M, Bok RA, Wang ZJ, Larson PEZ, Vigneron DB, Gordon JW.
Purpose: Improving the quality and maintaining the fidelity of large coverage abdominal hyperpolarize (HP) 13C MRI studies with a patch based global-local higher-order singular value decomposition (GL-HOVSD) spatiotemporal denoising approach.
Probing human heart TCA cycle metabolism and response to glucose load using hyperpolarized [2-13C]pyruvate MRS
Authors: Chen HY, Gordon JW, Dwork N, Chung BT, Riselli A, Sivalokanathan S, Bok RA, Slater JB, Vigneron DB, Abraham MR, Larson PEZ
Conclusions: HP [2-¹³C]pyruvate imaging is safe and enables noninvasive assessment of TCA cycle intermediates and acetylcarnitine, offering insights into cardiac metabolic flexibility not achievable with HP [1-¹³C]pyruvate.
Investigating cerebral perfusion with high resolution hyperpolarize [1-13C]pyruvate MRI
Authors: Hu JY, Vaziri S, Bøgh N, Kim Y, Autry AW, Bok RA, Li Y, Laustsen C, Xu D, Larson PEZ, Chang S, Vigneron DB, Gordon JW
Purpose: To investigate high-resolution hyperpolarized (HP) ¹³C pyruvate MRI as a noninvasive method for measuring cerebral perfusion and metabolic activity in the human brain, with the goal of enhancing diagnostic capabilities for neurological conditions.
