Daniel Vigneron, PhD

People

Daniel Vigneron
Principal Investigator
Professor

Daniel B. Vigneron, PhD, is a Professor in the Departments of Radiology & Biomedical Imaging, Bioengineering & Therapeutic Sciences and Neurological Surgery at the University of California, San Francisco. He is also Director of the UCSF Research Resource Program’s (RRP) Human Imaging Core Services recharge and the P41 NIH/NIBIB Hyperpolarized MRI Technology Resource Center. He is also the Operations Director of the Surbeck Laboratory for Advanced Imaging, Chair of the Radiology Research Safety & Compliance Committee, and a core member of the UCB/UCSF Graduate Group in Bioengineering at UCSF. Dr. Vigneron’s professional activities focus on the advancement of biomedical MRI research.

Dr. Vigneron’s research focuses on the development of advanced functional and metabolic Magnetic Resonance Imaging (MRI) techniques for both basic research and clinical assessments of human diseases. This requires the development of new hardware/software and MR protocols to provide biochemical and functional information in addition to the anatomic information provided by clinical MRI. This research has been reported in over 350 total publications resulting in over 43,000 citations with an h-index of 112 and an i10-index of 360 (Google Scholar) and has been funded by 27 NIH grants, including as PI: 3 P41 center grant awards, 2 P01, 2 U01, 18 R01 and 2 S10 shared equipment awards. Also 7 NIH mentored career awards as the Primary Mentor have been funded.

Dr. Vigneron’s research was initially focused on developing 3D MR spectroscopic imaging for the non-invasive assessment of brain tumor metabolism. Another major research interest of Dr. Vigneron’s is the characterization of prostate cancer using novel MR metabolic imaging techniques. Developing specialized acquisitions techniques for prostate cancer MRSI has been a major project for Dr. Vigneron and his group. These techniques have now been used in over 8000 research and clinical studies at UCSF. He also has led technical development aspects for the UCSF Hyperpolarized (HP) Carbon-13 MR molecular imaging program and is the PI for 6 projects including NIH P41 center grant, 2 RO1's, a P01, and a Bioengineering Research Partnership (BRP U01) focused on this new stable isotope molecular MR imaging approach. This exciting new technology detects not only the uptake of the HP molecule, but also its metabolic conversion rates in vivo.

Dr. Vigneron obtained his BA in Chemistry from Wesleyan University in Middletown, Connecticut in 1983, and he received his PhD in Pharmaceutical Chemistry from UCSF in 1988 for his graduate work on applying new MRI techniques for characterizing disease and therapy response. In 1990, he completed a postdoctoral fellowship from the Fox Chase Cancer Center in Philadelphia and in 1991 he completed a postdoctoral fellowship from UCSF.

Expertise:
Radiology and Biomedical Imaging

Specialty:
MRI, hyperpolarized MRI techniques, brain metabolism, prostate cancer

Professional Interests:
Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Molecular Imaging, Metabolic Imaging, Diffusion tensor imaging, Oncologic Imaging, Prostate Cancer Imaging, Pediatric Imaging, Brain MRI, Radiology.

Education and Training:
• Bachelor of Arts: Wesleyan University, Middletown, Connecticut - Chemistry, Pre-Med Studies
• Doctor of Philosophy: University of California, San Francisco - Pharmaceutical Chemistry
• Research Fellow: Fox Chase Cancer Center, Philadelphia
• Visiting Postdoctoral Scholar: University of California, San Francisco - Department of Radiology

Honors and Awards
Gold Medal Award, World Molecular Imaging Society, 2014
Distinguished Investigator Award, Academy of Radiology Research, 2013
Distinguished Service Award as Reviewer for Journal of Magnetic Resonance Imaging, International Society of Magnetic Resonance in Medicine, 2011
Awarded Fellow of ISMRM, International Society of Magnetic Resonance in Medicine, 2009
Elected to the College of Fellow, American Institute for Medical and Biological Engineering, 2007
Outstanding Presentation Award, American Society of Neuroradiology, 2007
Outstanding Presentation Award in Pediatric Neuroradiology - The Derek Harwood-Nash Award, American Society of Neuroradiology, 2001
Prostate Cancer Research Award, CaP Cure Foundation, 2000
Prostate Cancer Research Award, CaP Cure Foundation, 1999
Prostate Cancer Research Award, CaP Cure Foundation, 1998
National Research Service Award, National Cancer Institute, National Institutes of Health, 1990
Hawk Prize for Most Effective Work in Biochemistry, Wesleyan University, 1983

Publications

Consensus Recommendations for Hyperpolarized [1-13C]pyruvate MRI Multi-center Human Studies.

ArXiv

Punwani S, Larson PE, Laustsen C, VanderMeulen J, Ardenkjær-Larsen JH, Autry AW, Bankson JA, Bernard J, Bok R, Bertelsen LB, Che J, Chen AP, Chowdhury R, Comment A, Cunningham CH, Dang D, Gallagher FA, Gaunt A, Gong Y, Gordon JW, Grimmer A, Grist J, Hansen ESS, Lerche MH, Hesketh RL, Hoevener JB, Hsieh CY, Keshari KR, Kozerke S, Lanz T, Mayer D, McLean M, Park JM, Slater J, Tyler D, Vanderheyden JL, von Morze C, Zaccagna F, Zaha V, Xu D, Vigneron D, HP 13C MRI Consensus Group

New Horizons in Hyperpolarized 13C MRI.

Molecular imaging and biology

Chaumeil MM, Bankson JA, Brindle KM, Epstein S, Gallagher FA, Grashei M, Guglielmetti C, Kaggie JD, Keshari KR, Knecht S, Laustsen C, Schmidt AB, Vigneron D, Yen YF, Schilling F

Methodological consensus on clinical proton MRS of the brain: Review and recommendations.

Magnetic resonance in medicine

Wilson M, Andronesi O, Barker PB, Bartha R, Bizzi A, Bolan PJ, Brindle KM, Choi IY, Cudalbu C, Dydak U, Emir UE, Gonzalez RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Huppi PS, Hurd RE, Kantarci K, Kauppinen RA, Klomp DWJ, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marjanska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Mullins PG, Murdoch JB, Nelson SJ, Noeske R, Öz G, Pan JW, Peet AC, Poptani H, Posse S, Ratai EM, Salibi N, Scheenen TWJ, Smith ICP, Soher BJ, Tkác I, Vigneron DB, Howe FA

Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology.

Neoplasia (New York, N.Y.)

Kurhanewicz J, Vigneron DB, Ardenkjaer-Larsen JH, Bankson JA, Brindle K, Cunningham CH, Gallagher FA, Keshari KR, Kjaer A, Laustsen C, Mankoff DA, Merritt ME, Nelson SJ, Pauly JM, Lee P, Ronen S, Tyler DJ, Rajan SS, Spielman DM, Wald L, Zhang X, Malloy CR, Rizi R

Clinical proton MR spectroscopy in central nervous system disorders.

Radiology

Oz G, Alger JR, Barker PB, Bartha R, Bizzi A, Boesch C, Bolan PJ, Brindle KM, Cudalbu C, Dinçer A, Dydak U, Emir UE, Frahm J, González RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Howe FA, Hüppi PS, Hurd RE, Kantarci K, Klomp DW, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marjanska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Nelson SJ, Pamir MN, Pan JW, Peet AC, Poptani H, Posse S, Pouwels PJ, Ratai EM, Ross BD, Scheenen TW, Schuster C, Smith IC, Soher BJ, Tkác I, Vigneron DB, Kauppinen RA, MRS Consensus Group

A novel approach to high resolution fetal brain MR imaging.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

Rousseau F, Glenn O, Iordanova B, Rodriguez-Carranza C, Vigneron D, Barkovich J, Studholme C

SMRT Educational Seminars

Advances in Prostate MR Imaging: MR Spectroscopic Imaging at 1.5T and 3.0T.

Vigneron DB, Swanson MG, Kurhanewicz J.

Applied Radiology

Magnetic resonance spectroscopy principles and potential applications.

James TL, Chew WM, Gonzalez-Mendez R, Moseley M, Murphy-Boesch J, Pogliano L, Vigneron DB.